Too much use of MDMA, that is, more than twice a month, can cause depression later. Also, dudes that do it too much can have a tough time staying hard and popping. However, when you stop doing it for three or four months, the body readapts, and everything comes back. I can tell you this from experience. Just like with all other powerful drugs, the user continually chases that first high, but never gets it back. Don't do drugs. Intead, push for cheap disease test kits that do full panels (including herpes) so we can all safely fuck each other silly. We should demand that the price point of these kits, to be sold at all 7 - 11's, would be no more than $5. Truely safe sex would be the best drug, and would truly be 'ecstasy'. Getting tested only once a month is just ridiculous.