If you're worried about your liver with vicodin use, you could try taking a supplement called NAC (short for N-acetylcystein). It's what they give to people who OD on tylenol. I'm not sure how they administer it in the hospital, but taking an oral supplement of it whenever you pop some pills probably wouldn't be a bad idea.

I'm not a pillhead in general and have only tried the stimulant adderall once or twice. But I had a fantastic night once when I combined alcohol with an oxy and half of an adderall. It's like I was invincible and also super focused at the same time. And I felt like I could socialize with anyone and have a great time. But mostly I just stick with booze.