I've made several road-trips, when I was in the US.
From Porterville, CA, (between Bakersfield and Fresno) to Las Vegas and back. That was only 6 hrs or something, so it doesn't really count, I guess.
Another was from Porterville, CA, to New Orleans, non-stop. Mostly driving on Interstate 10. It was exhausting, but I saw a lot of beautiful landscapes.
Then back from New Orleans, via Kingman, AZ, to LAX.

Last one was from Indianapolis to Tunica, MS.