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A tougher question is what is the difference between a $3.99 bottle of wine and a bottle of cough syrup?
The good syrup has some codeine in it and will get you a better buzz if you can keep enough of it down. But you won't get it for $3.99.
I suggest Richard's Wild Irish Rose wine. Give a friend the first swig, you can tell if you have a good bottle by the look on his/her face.
Economics change, but normally you can get 3 fifths for one plasma donation.
-Chuck, Vegetarian fanboy