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Quinolones are a class of bactericidal agents that are well-absorbed and highly protein bound. They enter the bacteria via porin channels in Gram-negative bacteria and by lipophilicity in Gram-positive bacteria.1 The mechanism of action involves inhibiting two enzymes necessary for bacterial DNA synthesis, DNA gyrase and topoisomerace IV. Both are important in dictating DNA conformation. Gram-negative bacteria has a higher correlation with inhibition of DNA gyrase, while Gram-positive bacteria is more associated with inhibition of topoisomerase IV.4 The two affected enzymes have important roles in DNA synthesis.

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