Eat small, healthy meals spread out throughout the day, run like a rabid rottweiler is chasing your ass whenever you have free time, and, if you're doing this sans trainer, keep the weightlifting simple until you drop down to your goal weight. There's no need to do anything other than basic exercises to begin with. Worry about defining later.

And, as everyone already said, quit the pills. If by some miracle you do see positive results from taking them, the negative results -- break outs, agitation, panic attacks, sweating while you're inactive, etc. -- will be far more pronounced.