i got a minute to look up the stuff i'd heard about. the two guys at mclean's fucking virally-inserted the gene for shitty handling of dynorphin into rats. the rats became depressed, didn't eat, etc. they tested the stuff they thought would chemically block the right receptors in one group and let the others stay depressed.
then they fucking threw the things in water and forced them to swim, apparently the rats they drugged were vital enough to swim for their lives, the depressed ones basically were imbalanced enough that they couldn't muster much of an effort.
synopsis the abstract news after the test they're working on making a drug for humans